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Gonzalo M. Vazquez-Prokopec, Anuar Medina-Barreiro, Azael Che-Mendoza, Felipe Dzul-Manzanilla, Fabian Correa-Morales, Guillermo Guillermo-May, Wilbert Bibiano-Marín, Valentín Uc-Puc, Eduardo Geded-Moreno, José Vadillo-Sánchez, Jorge Palacio-Vargas, Scott A. Ritchie, Audrey Lenhart, Pablo Manrique-Saide
Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico
www.plosntds.org
www.plosntds.org
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/F8 1 Tf
(.)Tj
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[()6()9()-21()-13()12( )7(\n)]TJ
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[()6()9()-21()-13()12( )7(\n)]TJ
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Q
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(and)Tj
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(a)Tj
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(high-density)Tj
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(low-income)Tj
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(housing)Tj
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1.0374 0 Td
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1.4684 0 Td
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(29C)Tj
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(to)Tj
1.0261 0 Td
(34C)Tj
-34.8602 -1.2983 Td
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1.0318 0 Td
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2.0069 0 Td
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1.7801 0 Td
(rainy)Tj
2.2961 0 Td
(season)Tj
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(occurs)Tj
2.8346 0 Td
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2.2053 0 Td
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2.0013 0 Td
(to)Tj
1.0261 0 Td
(October)Tj
3.498 0 Td
(and)Tj
1.7291 0 Td
(overlaps)Tj
3.5319 0 Td
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2.0013 0 Td
(the)Tj
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(dengue)Tj
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2.8573 0 Td
(between)Tj
3.5262 0 Td
(July)Tj
1.7802 0 Td
(and)Tj
1.7291 0 Td
(November,)Tj
4.6885 0 Td
(although)Tj
3.753 0 Td
(cases)Tj
2.2224 0 Td
(occur)Tj
2.4718 0 Td
(year-round)Tj
4.7395 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.0749 0 Td
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-35.206 -1.2983 Td
(gue)Tj
1.6327 0 Td
(virus)Tj
2.2053 0 Td
(is)Tj
0.8448 0 Td
(widely)Tj
2.8232 0 Td
(distributed)Tj
4.5978 0 Td
(throughout)Tj
4.7792 0 Td
(the)Tj
1.4683 0 Td
(Yucatan)Tj
3.5206 0 Td
(peninsula,)Tj
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(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(vector)Tj
2.6985 0 Td
(control)Tj
3.1238 0 Td
(strat-)Tj
-35.2117 -1.2983 Td
(egies)Tj
2.1599 0 Td
(used)Tj
2.058 0 Td
(by)Tj
1.1849 0 Td
(local)Tj
2.0749 0 Td
(authorities)Tj
4.5014 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0147 0 Td
(this)Tj
1.6781 0 Td
(study)Tj
2.3868 0 Td
(included)Tj
3.7134 0 Td
(ultra-low)Tj
3.8834 0 Td
(volume)Tj
3.1975 0 Td
(\(ULV\))Tj
-32.3034 -1.3039 Td
(spraying)Tj
3.6396 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(organophosphate)Tj
7.166 0 Td
(insecticides)Tj
4.8132 0 Td
(chlorpyrifos)Tj
5.0626 0 Td
(and)Tj
1.7291 0 Td
(malathion)Tj
4.303 0 Td
(and)Tj
1.7291 0 Td
(indoor)Tj
2.948 0 Td
(space)Tj
-34.8545 -1.2982 Td
(spraying)Tj
3.6396 0 Td
(with)Tj
1.9956 0 Td
(pyrethroids)Tj
4.8472 0 Td
(\(deltamethrin\))Tj
6.0888 0 Td
(and)Tj
1.7291 0 Td
(organophosphates)Tj
7.5288 0 Td
(\(malathion\))Tj
4.9776 0 Td
(for)Tj
1.389 0 Td
(adult)Tj
/F9 1 Tf
2.2563 0 Td
[()30()]TJ
/F8 1 Tf
(.)Tj
/F9 1 Tf
-34.452 -1.2983 Td
[()6()9()-21()-13()12( )7(\n)]TJ
/F8 1 Tf
2.9876 0 Td
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3.3449 0 Td
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2.9594 0 Td
(published)Tj
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(reports)Tj
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2.2054 0 Td
(the)Tj
1.4683 0 Td
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(categorized)Tj
4.7735 0 Td
(the)Tj
1.4684 0 Td
(populations)Tj
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[()30()]TJ
/F8 1 Tf
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[()6()9()-21()-13()12( )7(\n)]TJ
/F8 1 Tf
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(1534C)Tj
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(below\))Tj
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(\(WP,)Tj
2.3074 0 Td
(5)Tj
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(7.5)Tj
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(125)Tj
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(sachet)Tj
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(7.5)Tj
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(water\))Tj
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(untreated)Tj
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3.118 0 Td
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2.9877 0 Td
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6.0321 0 Td
(doses)Tj
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2.0636 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
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(insecticide)Tj
4.4504 0 Td
(\(0.025)Tj
2.6872 0 Td
(g)Tj
0.686 0 Td
(active)Tj
2.5171 0 Td
(ingre-)Tj
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(dient)Tj
2.2847 0 Td
([a.i.]/m)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 252.6803 269.4614 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(2)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
-0.004 Tc
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(for)Tj
1.3889 0 Td
(deltamethrin)Tj
5.4028 0 Td
(and)Tj
1.7348 0 Td
(0.375)Tj
2.3471 0 Td
(g)Tj
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(a.i./m)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 396.9637 269.4614 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 402.7464 264.9826 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
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(for)Tj
1.3889 0 Td
(bendiocarb\))Tj
5.074 0 Td
(which)Tj
2.6475 0 Td
(were)Tj
2.126 0 Td
(applied)Tj
3.1521 0 Td
(using)Tj
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(standard)Tj
3.719 0 Td
(manual)Tj
3.2315 0 Td
(compression)Tj
5.3291 0 Td
(sprayers)Tj
3.5149 0 Td
(\(Hudson)Tj
3.7984 0 Td
(93793)Tj
2.5965 0 Td
(X-pert,)Tj
3.0614 0 Td
(Chicago,)Tj
3.7303 0 Td
(IL\))Tj
1.44 0 Td
(with)Tj
1.9956 0 Td
(flat)Tj
1.4853 0 Td
(nozzle)Tj
-33.902 -1.2983 Td
(fitted)Tj
2.3244 0 Td
(with)Tj
1.9956 0 Td
(flow)Tj
1.9445 0 Td
(control)Tj
3.1238 0 Td
(valves)Tj
2.5908 0 Td
(\(CFV)Tj
2.4491 0 Td
(red,)Tj
1.7632 0 Td
(model)Tj
2.7439 0 Td
(CFV.R11/16SYV.ST)Tj
8.0843 0 Td
(,)Tj
0.4422 0 Td
(with)Tj
1.9955 0 Td
(operating)Tj
4.0536 0 Td
(pressure)Tj
-33.5109 -1.3039 Td
(1.5Bar/21)Tj
4.0592 0 Td
(psi,)Tj
1.593 0 Td
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2.1827 0 Td
(rate)Tj
1.7518 0 Td
(550)Tj
1.6441 0 Td
(ml/min,)Tj
3.4752 0 Td
(CFValve,)Tj
3.8892 0 Td
(Gate)Tj
2.0918 0 Td
(LLC,)Tj
2.1883 0 Td
(Sebastian,)Tj
4.1896 0 Td
(FL\).)Tj
-25.8687 -1.2983 Td
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2.829 0 Td
(strong)Tj
2.7722 0 Td
(spatial)Tj
2.778 0 Td
(heterogeneity,)Tj
5.879 0 Td
(as)Tj
1.0148 0 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8504 0 Td
(observed)Tj
3.7927 0 Td
(for)Tj
/F9 1 Tf
1.3889 0 Td
[()30()]TJ
/F8 1 Tf
(.)Tj
/F9 1 Tf
1.491 0 Td
[()6()9()-21()-13()12( )7(\n)]TJ
/F8 1 Tf
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(],)Tj
2.075 0 Td
(randomly)Tj
4.1272 0 Td
(allocat-)Tj
-33.9644 -1.2982 Td
(ing)Tj
1.5023 0 Td
(treatments)Tj
4.4958 0 Td
(over)Tj
1.9729 0 Td
(space)Tj
2.3811 0 Td
(can)Tj
1.627 0 Td
(lead)Tj
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